Publications

bookshelf

 

“Small-Molecule Inhibition of the Interaction between the Translation Initiation Factors eIF4E and eIF4G.” Nathan J. Moerke, Huseyin Aktas, Han Chen, Sonia Cantel, Mikhail Y. Reibarkh, Amr Fahmy, John D. Gross, Alexei Degterev, Junying Yuan, Michael Chorev, Jose Halperin, and Gerhard Wagner, Cell 128(2) pp. 257 – 267 (January 26, 2007).

“Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia.” Blood (Aug 20, 2009) 114(8):1618-27.

“Mechanisms of translational deregulation in human tumors and therapeutic intervention strategies.” Oncogene 26, 5973-5990 (April 2, 2007).

“Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity.” Journal of Clinical Investigation, 117:2638–2648 (2007).

“Repression of Cap-Dependent Translation Attenuates the Transformed Phenotype in Non–Small Cell Lung Cancer Both In vitro and In vivo.” Cancer Research 66, (April 15, 2006) 4256-4262.

“Structure-activity requirements for the antiproliferative effect of troglitazone derivatives mediated by depletion of intracellular calcium.” Bioorganic & Medicinal Chemistry Letters 14, 2547-50, (May 17, 2004).

“Translation Initiation in Cancer: A Novel Target for Therapy.” Molecular Cancer Therapeutics, (September 1, 2002) vol. 1 no. 11, 971-979

“Translational Control of the Proteome: Relevance to Cancer” Proteomics 1, 1191-1199 (October 8, 2001).

“Inhibition of Translation Initiation Mediates the Anticancer Effect of the n-3 Polyunsaturated Fatty Acid Eicosapentaenoic Acid.” Cancer Research 60, 2919–2925, (June 1, 2000).

“Translational Control: the Cancer Connection." The International Journal of Biochemistry & Cell Biology 31 (Feb 1999) 73-86

“eIF4E Expression in Tumors: Its Possible Role in Progression of Malignancies.” The International Journal of Biochemistry and Cell Biology 31, 59-72 (January 1999).

“Depletion of intracellular Ca ++ stores, phosphorylation of eIF2a, and sustained inhibition of translation initiation mediate theanticancer effects of clotrimazole.” Proc. Natl. Acad. Sci.USA, 95, 8280–8285, (July 1998).

“Clotrimazole inhibits cell proliferation in vitro and in vivo.” Nature Medicine  1, 534 - 540 (1995).